RNA Details
Disease Name
cystic fibrosis
Tissue
lung
RNA Symbol
Cav1
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
In vivo experiment and BAL fluid collection and analysis; qRT-PCR; etc.
Target
Cav1
Pathway
AKT/MIR-199A-5P/CAV1 signaling pathway
PubMed ID
Title
Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation
Year
2015
Function
"In CF macrophage, activated PI3K/AKT pathway increase miR-199a-3p expression, reduce expression of CAV1, leading to increased TLR4 signaling and inflammation. Celecoxib re-establishes the AKT/miR-199a-5p/CAV1 axis in CF macrophages, and ameliorates lung hyper-inflammation in Cftr-deficient mice."